Spotlight on Research

Sidney Eisig, DDS

Tracking Cells and Biomaterials Remodeling in Tissue Engineered Bone Grafts

January 18, 2018

Research led by Dr. Sidney Eisig, DDS, Chief of Hospital Dental Service at New York-Presbyterian Hospital, is exploring the tissue engineered bone graft method of action and the fate of the implanted cells. The research aims to provide key information about the implanted stem cells concerning their function in reconstruction and site-localized safety. Dr. Eisig explained the study’s broad implications.

“These results will not only benefit the clinical translation of tissue engineered bone grafts, but will provide important information to educate decisions regarding cell activity in tissue engineering applications in any targeted tissue.” He added that the project has greater value as well – by “helping teach residents to participate in writing a grant proposal, in submitting to the University Animal Use Committee, and in actively participating in all phases of the project, from animal surgery to bench top research, to analysis.”

Tissue engineered bone grafts present an attractive solution to the complexity involved in oral and maxillofacial bone grafts. Despite the functional success with tissue engineered bone grafts for bone reconstruction, little is known concerning the tissue engineered bone graft method of action and the fate of the implanted cells. In Dr. Eisig’s study, the implanted cell localization and contribution to bone regeneration will be investigated in a rat calvarial defect model. Utilizing genetically altered rat adipose derived stem cells (ADSCs) to fabricate our scientifically proven tissue engineered bone grafts, the objectives of the study will provide key information about the implanted stem cells concerning their function in reconstruction and site-localized safety. These results will not only benefit the clinical translation of tissue engineered bone grafts, but will provide important information to educate decisions regarding cell activity in tissue engineering applications in any targeted tissue.

Dr. Eisig is Chief of Hospital Dental Service at New York-Presbyterian Hospital, and the William Carr Professor and Director of Oral and Maxillofacial Surgery at both the Hospital and Columbia University School of Dental and
Oral Surgery.

CONTACT

Osteo Science Foundation
1650 Market Street, Suite 3600
Philadelphia, PA 19103
215-977-2877
855-891-2877 Toll Free
info@osteoscience.org

Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization.

SIGN UP FOR NEWS

%d bloggers like this: